San Francisco is a 2.5-point favorite in the latest 49ers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 48.5. The 49ers are -151 money line favorites (risk $151 to win $100),

The San Francisco 49ers may be without Yetur Gross-Matos for at least four weeks because of a setback with his hamstring injury.

Preview the Week 9 matchup between the San Francisco 49ers and New York Giants with predictions, odds, over/under, spread, betting lines and more.

Following two road games that were each brutal in their own way, the New York Giants (2-6) return home to face the San Francisco 49ers (5-3) in Week 9. 61-year-old John Hussey will greet them, the head official for Sunday afternoon's showdown.

The New York Giants take on the San Francisco 49ers in Week 9, and here are the three best prop bets from that game.

Many teams, including the Rams, 49ers, Lions, Colts and Eagles, have called the Bengals on numerous players, including LB Logan Wilson, CB Cam Taylor-Britt and, of course, DE Trey Hendrickson. For now, some teams don’t believe Cincinnati has any real interest in moving its core pieces.

The San Francisco 49ers' roster has been in flux all year, and that's not changing just one day before their matchup with the New York Giants.

The San Francisco 49ers have placed defensive lineman Yetur Gross-Matos on injured reserve after he re-injured his hamstring during practice.

The 2025 season has been a nightmare for San Francisco 49ers quarterback Brock Purdy. That's because he's been dealing with a turf toe injury since Week 1. Purdy has been sidelined since Sept. 28. Mac Jones has filled in at quarterback during the former Mr.