Cell division, the basic means by which genetic information is passed from generation to generation, involves tightly coordinated movements of a cell's DNA. This page describes the major phases of ...

Which end of the kinetochore fibre shortens and whether shortening actively drives or passively permits polewards chromosome movement represent enduring problems in understanding anaphase ...

Ubiquitination by the anaphase-promoting complex (APC/C) is essential for proliferation in all eukaryotes. The human APC/C promotes the degradation of mitotic regulators by assembling K11-linked ...

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...