We often hold it to be self-evident that antibodies are key to an effective immune response against a pathogen—the more (or more potent) antibodies your body makes, the better it will fight off an ...

Antibody-mediated rejection is a leading cause of kidney-transplant failure. The targeting of CD38 to inhibit graft injury caused by alloantibodies and natural killer (NK) cells may be a therapeutic ...

Riliprubart is being evaluated in a phase 2 trial for the prevention and treatment of antibody-mediated rejection. The Food and Drug Administration (FDA) has granted Orphan Drug designation to ...

The efficacy of allogeneic cell therapeutics for regenerative or oncology indications can be compromised by the emergence of antibodies against those cells, as observed in clinical trials. To overcome ...

The first study, by Everly and colleagues, was a retrospective single-center analysis of 52 kidney transplant recipients with biopsy-proven acute rejection diagnosed between January 1, 2003, and ...

Editor’s note: On September 22, 2023, a U.S. Center for Disease Control advisory board recommended that an RSV vaccine, made by Pfizer, be given between the 32nd and 36th week of pregnancy. Pregnant ...

Age could be a dominant factor in influencing antibody production in response to a virus -- for a given virus, certain antibodies increase with age while others decrease, depending on which part of ...

A promising antibody failed testing. This is good news for developing a broad-spectrum antidote against the world's most dangerous snake venoms. What makes a soldier switch sides? That is a really ...

San Diego, CA (October 26, 2024) — Chronic active antibody-mediated rejection (caAMR) is a common cause of allograft loss after transplantation, with no approved therapies. Clazakizumab, a monoclonal ...