The human CTLA-4 gene is located on 2q33, in a susceptibility region for autoimmune diseases. Several single-nucleotide polymorphisms have been described within the CTLA-4 gene. Among these ...

T cells are the 'foot soldiers' that fight cancer inside the body. Cancer cells can fight the foot soldiers back by pushing a brake on the T cells that will turn them off. This 'brake' is a molecule ...

Studies performed during the past 2 years have provided a deeper understanding into the role of CTLA-4, which is expressed on regulatory T cells, in preventing autoimmunity, and also provide ...

Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an immunogenic protein receptor that is expressed almost exclusively on CD4+ and CD8+ T cells. It plays a crucial role in the homeostasis of ...

Preliminary findings from part 1 of COMBI-i: A phase III study of anti–PD-1 antibody PDR001 combined with dabrafenib (D) and trametinib (T) in previously untreated patients (pts) with advanced BRAF ...

Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells. Blocking CTLA-4 with a specific antibody is an ...

Development of a novel granulocyte scoring system for use as a predictive/prognostic biomarker in patients with advanced melanoma undergoing treatment with combination immunotherapy. This is an ASCO ...

We are writing to provide clarification and correction to our article “Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma” (Dec. 4, 2014, issue). 1 Along with the publication, ...

Antibodies targeting cytotoxic T-lymphocyte protein 4 (CLTA-4) have faced challenges due to frequent adverse events and limited efficacy, thus pushing the search for next-generation anti-CTLA-4 ...

Researchers discovered that an immunotherapy, called anti-CTLA-4, mobilizes microglia against glioblastoma as it causes CD4+ T cell infiltration of the brain. A study led by Salk Institute (CA, USA) ...

T cells are the 'foot soldiers' that fight cancer inside the body. Cancer cells can fight the foot soldiers back by pushing a brake on the T cells that will turn them off. This 'brake' is a molecule ...