Caspase and caspase-like proteases (termed metacaspases) are a conserved group of proteins that are present in multicellular and unicellular eukaryotes, as well as several prokaryotes. In the ...

Expression profiles associated with disease progression in non-small cell lung cancer. Background: Cisplatin is a platinum-based chemotherapeutic drug used for treating a variety of human cancers such ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

The enzyme caspase-8 regulates different modes of cell death, according to new research. The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic ...

Caspases are proteases: enzymes that catalyze the breakdown of proteins and are part of the cysteine–aspartic acid protease family. They are vital to the mechanism of programmed cell death in animals ...

Here’s what you’ll learn when you read this story: When cells are about to die, they send signals that trigger proteins which are supposed to destroy them, but it doesn’t always happen that way. Some ...

A new study offers important mechanistic insights into a recently discovered CRISPR-guided caspase, or Craspase. Using cryo-electron microscopy (cryo-EM), researchers explained its target RNA cleavage ...

Researchers have revealed insights into the mechanism of how coronaviruses including SARS-CoV-2, SARS-CoV-1, and MERS-CoV exploit a host protease called 'cysteine-aspartic protease 6' (caspase-6) for ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human health and disease. This focus has evolved to include the investigation of ...

Blocking an immune response-related enzyme holds promise in preventing or treating severe COVID-19 symptoms by reducing inflammation, tissue injury and blood clots in the lungs, new research in mice ...