The c-Jun N-terminal kinase (JNK) signaling pathway mediates adaptation to stress signals and has been associated with cell death, cell proliferation, and malignant transformation in the liver.

According to PKD International, 12.5 million people are affected by polycystic kidney disease. There is no known cure. But that may one day change, thanks in part to new research by a Concordia ...

Researchers from Yale School of Medicine, Ionis Pharmaceuticals Inc. and the National Institutes of Health have published data from a study that aimed to identify the signaling pathways involved in ...

PKD is mainly caused by mutations in the PKD1 and PKD2 genes, affecting polycystin proteins. Disrupted signaling pathways, like cAMP and vasopressin, are major drivers of cyst growth. Tolvaptan is ...

Ovarian cysts are very common in people who menstruate, with an estimated 10% to 30% of women — and potentially more — developing at least one in their lifetime. These fluid-filled sacs develop in or ...

Ovarian cysts are fluid-filled sacs that form on or inside the ovaries for a variety of reasons. Often, they disappear on their own, but sometimes, they can grow very large, burst or cause an ovary to ...