Natural products derived from microorganisms are a promising source of new active ingredients, but are often produced only in ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 52 (December 30, 2014), pp. 18454-18459 (6 pages) Enzymes use protein architectures to create highly ...

Methanotrophic bacteria consume 30 million metric tons of methane per year and have captivated researchers for their natural ability to convert the potent greenhouse gas into usable fuel. Yet we know ...

Exo Therapeutics raised $78 million in series B financing to develop a new strategy for drugging enzymes. Many drugs work by blocking target enzymes’ active sites, which perform reactions like ...

Bacteria constantly evolve new ways to evade antibacterial drugs. One emerging resistance mechanism involves an enzyme called New Delhi metallo-β-lactamase-1 (NDM-1). NDM-1 can hydrolyze most ...

A team has used neutron crystallography to image all of the atoms in a radical intermediate of a copper amine oxidase enzyme. They disclosed previously unknown details, such as precise conformational ...

Chemistry researchers at the University of Utah have uncovered an enzyme, dubbed PapB, that can "tie off" therapeutic ...

Amides and thioesters are ubiquitous compounds in chemistry, used for the production of medicines, natural products, and advanced materials. Traditionally, their synthesis is a messy business, ...