Which end of the kinetochore fibre shortens and whether shortening actively drives or passively permits polewards chromosome movement represent enduring problems in understanding anaphase ...

(Phys.org) -- With the first-ever three-dimensional image of an isolated kinetochore – the bulky molecular machine that connects a chromosome to the long, thin microtubules that tug it to one end of a ...

Chromosome segregation during cell division is enacted by the mitotic ‘spindle’. Chromosomes connect to the spindle through kinetochores that capture microtubules and attach to their plus ends, the ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 48 (November 30, 2021), pp. 1-11 (11 pages) Kinetochores, a protein complex assembled on centromeres, ...

Thousands of our cells successfully divide every day. They replicate their DNA and then separate so that each of the new cells has the same complement of chromosomes. If the process goes wrong and ...

During mitosis, replicated chromosomes are separated to daughter cells by the microtubule-based mitotic spindle. Chromosomes attach to the mitotic spindle through specialized DNA/protein structures ...

As a human cell begins division, its 23 chromosomes duplicate into identical copies that remain joined at a region called the centromere. Here lies the kinetochore, a complicated assembly of proteins ...

Crowning a quest into a very well-guarded secret: Structure of the kinetochore corona finally revealed Date: April 8, 2022 Source: Max Planck Institute of Molecular Physiology Summary: During cell ...

To establish a functional kinetochore, the microtubule-binding Ndc80 complex (Ndc80C) must be recruited into the kinetochore. While a previous model suggested that CENP-C is a main recruiter for ...

Cell division is vital for the continuation of life. If something goes wrong in, say, the distribution of chromosomes, abnormalities or serious diseases such as cancer may result. This is why ...

The cell cycle, the biological process underlying how cells grow and multiply, is tightly regulated to ensure a faithful distribution of genetic material to ‘daughter’ cells. This tight regulation of ...

During cell division the 23 chromosomes must be first copied and later delivered to two newly forming daughter cells. At least in healthy cells, the result is astonishingly flawless, and no chromosome ...