Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the ...
(A) The images show MLRO in primary cultured mouse hepatocytes. The bar scale is 500 nm. (B) The proposed model illustrates how lysosomes and TFEB regulate MLRO in hepatocyte dedifferentiation.
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