Pancreatic organoids reveal how lumen shape is controlled by the balance between cell proliferation, internal pressure, and epithelial permeability.

Working with three-dimensional pancreatic models (organoids), derived from mouse cells, researchers combined computer simulations with experiments to find out what controls the shape of lumens ...

For organs to develop, grow and regenerate, cells must proliferate. But when that process goes awry, leading to uncontrolled cell growth, cancer can emerge. New CU Boulder research, published in the ...

Technologies at the Advanced Rodent Transgenics Laboratory include genome editing design and implementation and transgenic ...

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at the base of crypts. While ISCs play an essential role in epithelial ...