The second half of the 2025 NFL regular season is about to begin. If the final nine weeks of the year are anything like the first, we're in for a wildly entertaining stretch run. It kicks off with a Week 10 slate that features a number of intriguing matchups - including Sauce Gardner making his Colts debut after a shocking deadline blockbuster,

Houston Texans running back Nick Chubb (21) rushes for yards during the fourth quarter of an NFL football matchup at EverBank Stadium, Sunday, Sept. 21, 2025, in Jacksonville, Fla. The Jaguars defeated the Texans 17-10. / Corey Perrine/Florida Times-Union / USA TODAY NETWORK via Imagn Images

The Indianapolis Colts are coming off a loss. The Atlanta Falcons have lost three straight. NFL Week 10 predictions, picks.

I'll bite on the Panthers following their upset win over the Green Bay Packers. This is actually the first time Carolina has been favored over New Orleans since 2017! It's warranted, as the Saints are 2-7 ATS on the year, which is the worst mark in the NFL .

The Josh Allen-Patrick Mahomes dance at the top of the MVP odds board took a twirl after the Buffalo Bills beat the odds and the Kansas City Chiefs on Sunday. Allen, who spent a few weeks atop the odds board before Mahomes vaulted over him in Week 6, took the lead back with that win.