The second half of the 2025 NFL regular season is about to begin. If the final nine weeks of the year are anything like the first, we're in for a wildly entertaining stretch run. It kicks off with a Week 10 slate that features a number of intriguing matchups - including Sauce Gardner making his Colts debut after a shocking deadline blockbuster,

Microsoft Copilot once again extended its streak of winning weeks making NFL picks. Can the AI chatbot have another one in NFL Week 10?

NFL Week 10 picks, predictions for games this week, including Bills-Dolphins, Ravens-Vikings, Lions-Commanders, Steelers-Chargers, Eagles-Packers.

A nother week, another round of must-see matchups across the NFL. One week after some stunning developments, like the Bo Nix-led Denver Broncos routing the Dallas Cowboys and the Baltimore Ravens blowing out the Chicago Bears despite missing Lamar Jackson , we've got another slate full of intriguing action in Week 9.

All odds referenced are courtesy of BetMGM as of publish time.

NFL Week 10 picks, predictions, win probabilities for Raiders-Broncos, Falcons-Colts, Jaguars-Dolphins, Browns-Jets, Cardinals-Seahawks, more games.