The first half of the 2025 NFL season is in the books, so it's time to get ready for Week 10. The top teams in each conference are battling it out to improve th

Week 10 of the 2025-26 NFL regular season officially kicks off on Thursday, October 6, with a primetime showdown in the AFC West. The Denver Broncos will aim to keep their six-game winning streak going when they welcome the struggling Las Vegas Raiders to Mile High.

SportsLine AI evaluated the Week 10 NFL odds and revealed its NFL predictions, NFL score predictions and NFL betting picks for every game

Microsoft Copilot once again extended its streak of winning weeks making NFL picks. Can the AI chatbot have another one in NFL Week 10?

Spread: Broncos -10 Moneyline: Broncos -520, Raiders +390 O/U: 42.5 Spread: Colts -6.5 Moneyline: Colts -325, Falcons +260 O/U: 48.5 Spread: Buccaneers -2.5 Moneyline: Buccaneers -135, Patriots +114 O/U: 48.5 Spread: Bills -8.5 Moneyline: Bills -410, Dolphins +320 O/U: 50.5 Spread: Ravens -3 Moneyline: Ravens -175, Vikings +145 O/U: 48.5

The 4-4 Minnesota Vikings are coming off a good win at the Detroit Lions and getting no respect at all this week. They're 4-point home underdogs against the Ravens at BetMGM. We're about to find out if oddsmakers' faith in the Ravens is justified.

The New York Giants (2-7) visit the Chicago Bears (5-3) at Soldier Field in Chicago for a Week 10 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions for the action. Here's everything you need to know before kickoff on Sunday, November 9, including live updated odds and injury report news.

The young Vikings’ quarterback showed promise last week in an upset win against the Lions, but still hasn’t cracked 160 passing yards in his three career starts. The Vikings will try to win this one with their running game and defense, so expect another modest stat line from McCarthy.

Our Week 10 picks for the 2025 NFL season are in! Bleeding Green Nation staff members are here to predict the winners of every game on the schedule. We’ll tally the results along the way and see who comes out on top at the end of the season. Feel free to post your own predictions or discuss the writer predictions in the comments.

While keeping a positive game script, the Bills out-physicaled the Chiefs and won the line of scrimmage. Running back James Cook went over 100 yards, and establishing that helped Bills quarterback Josh Allen gash the Chiefs defense on another of its weak points this season: play action.

Here are the top sportsbook promos for new users ahead of the 2025 Week 10 NFL schedule.