Florio's pick: 49ers 27, Seahawks 24. Simms's pick: Seahawks 28, 49ers 24. A meaningless game will have plenty of meaning, if Tampa wins on Saturday. Florio's pick: Saints 23, Falcons 20. Simms's pick: Falcons 24, Saints 17.

Sam Farmer makes his picks and predictions for the final week of the NFL regular season, with the 49ers beat the Seahawks and the Steelers prevailing.

We're down to the final week of the 2025 regular season. Playoff teams are figuring out whether to play their starters or go with backups to avoid key injuries. So, what's the motivation for clubs eliminated from postseason contention?

Picking the Ravens over the Steelers is almost too easy. We also like the Seahawks over the 49ers and Bucs over Panthers in critical games.

For some, this year is already over and it's all about the upcoming 2026 offseason, and more importantly, the draft. Week by week, more teams will fall into this area, making where their selection sits in Round 1 all the rage.