The capacity of a plasmid to express genes is constrained by its length and copy number. However, the interplay between these parameters and their constraints on plasmid evolution have remained ...

Plasmid coupling creates heterogeneity in copy number and, therefore, expression across a microbial population. We demonstrate that plasmid-encoded fitness differences between individuals can then ...

Conjugative plasmids are extrachromosomal genetic elements that carry genetic determinants for adaptive traits. They contribute to the global dissemination of antibiotic resistance among ...

Plasmid DNA isolation is an important technique in molecular biology, however, achieving effective high-throughput automation of this method has proven to be challenging. Analytik Jena and SynbiCITE ...

DNA vaccines, wherein a new antigen is inserted into a validated vector, have tremendous potential for deployment in pandemic applications as they can be rapidly produced in a validated, ...