Protease‐activated receptors (PARs) play a central role in platelet activation and thrombosis. These G protein‐coupled receptors are activated through proteolytic cleavage, which unmasks a tethered ...
Researchers at New York University have demonstrated that protease-activated receptor 2 (PAR2) on epithelial cells of the colon continued after they were trafficked from the cell membrane.
Abdominal pain is a hallmark of many digestive disorders, including inflammatory bowel disease and irritable bowel syndrome. In an effort to develop targeted treatments for gut pain, scientists have ...
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Microbiome and nanoparticle discoveries hold promise for treating gut pain
“The results were black and white: if the protease was present ... the researchers sought to exploit a known behavior of PAR 2: when the receptor is activated, it moves from the surface of cells ...
No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2004 ASCO Annual Meeting. This abstract does not include a full text component.
Ying Lin, Jacob M. Wozniak, Neil J. Grimsey, Sravan Girada, Anand Patwardhan, Olivia Molinar-Inglis, Thomas H. Smith, John D. Lapek, David J. Gonzalez, JoAnn Trejo Proceedings of the National Academy ...
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