Researchers led by a team from the University of Bath in the UK have achieved just that in a basic worm model of Parkinson's.

Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases. To overcome these limitations, scientists developed the real-time quaking-induced ...

Yeast prions are increasingly recognised as pivotal agents in non-Mendelian inheritance, whereby protein conformations rather than nucleic acids dictate heritable traits. In Saccharomyces cerevisiae ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle wasting and limb ...

The formation of amyloid fibrils and the aggregation of misfolded proteins are central to the pathology of Alzheimer’s disease. At the molecular level, normal proteins adopt aberrant conformations ...

Many neurodegenerative disorders, such as Parkinson’s disease, share the hallmark of functional proteins forming deposits ...

Researchers at the VIB-KU Leuven Center for Microbiology and the VIB-KU Leuven Center for Brain & Disease Research revealed a mechanism involving protein aggregation that allows bacteria to enter a ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region ...

Scientists discovered that specific nutrients in nematodes' diets activate stress defenses that keep their cells healthier over time. These RNAs prevent toxic protein buildup, promoting longevity and ...

The pathway leading to the telltale sign of ALS, protein aggregation in the cytoplasm of motor neurons, has been revealed. Researchers from the University of California – San Diego (CA, USA) have ...

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates found in Alzheimer's disease, pointing towards a new potential therapeutic ...

The new treatment leverages peptide-brush polymers, which act as a shield to prevent proteins from binding to one another. Polymer backbone is shown in yellow. Active peptides are in blue and green.