Protein splicing is a naturally occurring post‐translational process in which inteins, as self‐excising protein segments, precisely remove themselves from a host polypeptide and concomitantly ligate ...

An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this mechanism is disrupted, the blueprints used by the cell to produce proteins are ...

This diversity is enabled by a process known as "splicing." When a cell requires a protein, it generates a copy of the ...

The Living Brain Project (LBP) is a collaborative research initiative led by the Icahn School of Medicine at Mount Sinai. Its mission is to generate, analyze, and openly share the world’s first ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids. From stabilising cell structure to catalysing chemical reactions, ...

Researchers at the Centre for Genomic Regulation show that cancer doesn’t invent new tricks—it reawakens embryonic splicing ...

Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...

CSHL’s Krainer lab used a technique called live-cell fluorescence imaging to observe the DDX23 enzyme (above, in green) in action. Together with the critical regulator protein SRSF1, DDX23 helps set ...

An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this mechanism is disrupted, the blueprints used by the cell to produce proteins are ...