Immobilized metal affinity chromatography (IMAC) is a reliable method for isolation of recombinant protein following over-expression in Escherichia coli. The polyhistidine tag (6–10 consecutive amino ...
What is now a standard protein laboratory technique began as an act of desperation. What is now a standard protein laboratory technique began as an act of desperation. In the late 1960s, two ...
Tumor necrosis factor ligand superfamily member 9 (4-1BBL), also known as 4-1BB ligand, CD137L, or TNFSF9, is a cytokine that binds to TNFRSF9. It serves as the high-affinity ligand for 4-1BB and ...
G protein-coupled receptors (GPCR) are a large and diverse class of plasma membrane receptors involved in transduction of extracellular signals. The range of GPCR ligands is broad and includes small ...
A research team led by Prof. Xu Pingyong from the Institute of Biophysics of the Chinese Academy of Sciences has developed an ...
In drug discovery, high hopes ride on degradation-based methods as a strategy to target proteins that are not easily subdued by classical inhibitors. And in basic research, too, degradation can ...
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