Over the past decade, however, a wave of technological advances has begun to expand the druggable proteome. These include covalent inhibitors (such as sotorasib), chemical proteomics, and AI-enabled ...

The global Human Proteome Project released its 2023 report describing new proteins identified in the past year, as well as new work beginning to characterize the functions of these proteins. The ...

Following on from his exposé of the dearth of specificity in our vocabulary surrounding the proteome and his emphasis that individual proteoforms should be the focus of our proteomic investigations, ...

Development and validation of a gene expression signature based on RB1, PTEN, and TP53 in patients with metastatic hormone-sensitive prostate cancer (mHSPC).

A new study maps the biological influences on thousands of plasma proteins, revealing potential disease biomarkers and drug targets, providing hope for more precise, personalized treatments. Study: ...

Researchers from the MPI of Biochemistry and the Technical University of Munich have discovered new diagnostic markers for multiple sclerosis (MS), a disease that affects 3 million people worldwide.

A multicellular system isn’t a system just because it has many cells. The cells must be of different types. Indeed, a great many different cell types are needed. To distinguish as many cell types as ...

A milestone in biology has been achieved thanks to artificial intelligence (AI) machine learning and applied physics. A new peer-reviewed study by researchers affiliated with Harvard John A. Paulson ...

Explore how proteomics transforms pharmaceutical R&D, from drug discovery to biomarker qualification and clinical development ...

Proteomics began with the development of 2D gel electrophoresis in the 1970s. The technique enabled the large-scale separation and analysis of proteins by isoelectric point (the pH at which the ...