Adenylosuccinate lyase (ADSL) deficiency is an inherited metabolic disorder that impairs purine metabolism. ADSL is a key enzyme in both the de novo synthesis and the purine nucleotide cycle, ...

Parkinson's disease (PD), the second most common neurodegenerative disorder globally, has long baffled scientists with its progressive nature and debilitating effects on motor function. A recent study ...

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules, and energy carriers. Treatments that inhibit their synthesis offer a ...

Researchers are one step closer to understanding how pediatric DIPG tumors work. Researchers at the University of Michigan Health Rogel Cancer Center are one step closer to understanding how pediatric ...

Researchers recently discovered that patients with Parkinson's disease exhibit lower levels of uric acid and impaired energy recycling. It challenges previous beliefs about uric acid's role in the ...