Researchers at the University of Hawaiʻi at Mānoa have developed new mouse models to study a key male fertility gene, ...

Humanized mouse models are vital for studying human gene function, but fully replacing mouse genes with complete human ...

Respiratory infections are among the leading causes of illness and death in the elderly, driven by immune aging, chronic ...

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most ...

Cannabidiol (CBD) could become a therapeutic tool to address some of the most frequent and disabling consequences of fetal ...

Preclinical data suggest neratinib dampens vascular inflammation and atherosclerosis by targeting ASK1 in endothelial cells, ...

A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

Spinal deformities such as scoliosis and kyphosis are among the most serious complications of neurofibromatosis type 1 (NF1), a genetic disorder that affects about one in 3,000 people.

An international research team led by Baylor College of Medicine and The University of Osaka have found a way to resume sperm production, leading to healthy offspring in mouse models with ...