A major problem in solid-phase peptide synthesis (SPPS) is aggregation and poor solvation leading to incomplete deprotection and/or coupling steps, resulting in low crude purity peptides. 1 This ...

The peptide lab is designed to produce a range of molecules, including linear peptides, cyclic peptides, and peptide-drug conjugates.

Bruce Merrifield, who died Sunday at 84, won the 1984 Nobel Prize in Chemistry for creating a method for rapidly synthesizing proteins and peptides. Merrifield developed the method, known as solid ...

In 1901, the German chemist Emil Fischer synthesized the first pure dipeptide molecule; more than half a century later, most chemists were still using the same technique of adding and removing ...

Inside our cells, ribosomes—the tireless "protein factories" of life—have just shown off a new skill they haven't used in billions of years. A research team has become the first in the world to ...

Explore how an integrated approach accelerates cyclic peptide discovery, combining innovative methods to improve efficiency.

Microbiologist Cesar de la Fuente searches organisms’ genomes, including those that are long gone, to find “encrypted ...

Bruce Merrifield, whose greatly accelerated process for making proteins helped develop an array of medications and earned him the 1984 Nobel Prize in chemistry, has died. He was 84. Dr. Merrifield ...

Schematic illustrating the preparation of fluorophore-labelled ubiquitin (top) and the chemical structure of an analogue of goadsporin, a narrow-range antibiotic against Gram-positive bacteria (bottom ...