tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

In 1965, Cornell biochemist Robert Holley deciphered the 77 nucleotide sequence of transfer RNA. Three years later, Holley was awarded the Nobel Prize for this work, but already the race to determine ...

Transfer ribonucleic acid (tRNA) is a type of RNA molecule that helps decode a messenger RNA (mRNA) sequence into a protein. tRNAs function at specific sites in the ribosome during translation, which ...

In all living organisms, the biomolecule transfer RNA (tRNA) plays a fundamental role in protein production. tRNAs are generated from precursor molecules in several steps. The enzyme tRNA splicing ...

Many viruses have genomes made of RNA. In human cells, messenger RNA (mRNA) molecules act as intermediates; cellular machinery copies a DNA sequence into mRNA so that it can then be translated into a ...

The chemical steps involved in an important cellular modification process that adds a chemical tag to some RNAs has been revealed in a new study. Interfering with this process in humans can lead to ...

RNAs play an integral part in all kingdoms of life and mediate critical processes from gene regulation to genomic maintenance and protein synthesis. RNAs also have an amazing diversity in structure ...

For disorders driven by a known genetic component, research understandably focuses on developing a drug targeting that genetic signature. When that works, the outcome benefits patients but the end ...

The Series A round of funding announced Wednesday was led by a syndicate that includes ARCH Venture Partners, Takeda Ventures, and 8VC. The cause of many diseases are dysfunctional proteins. In some ...

Predicting RNA (ribonucleic acid) structures may help accelerate the discovery and development of new drugs to treat diseases and disorders. A new Stanford study published in Science uses artificial ...

UNIVERSITY PARK, Pa. — The chemical steps in an important cellular modification process that adds a chemical tag to some RNAs have been revealed in a new study. Interfering with this process in humans ...