Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic acid residues in eukaryotic ...
This study provides novel insights into the elongation dynamics of eukaryotic cells and the counteracting mechanisms in place to reduce translation defects during protein synthesis. "Understanding the ...
Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like ...
Diphthamide is a unique post‐translational modification found on a specific histidine residue of eukaryotic translation elongation factor 2 (eEF2). This modification is critical for ensuring ...
Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like ...
Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of ...
Advances in molecular biology have revealed that pep-tRNAs—nascent polypeptides inside the ribosome that are covalently attached to transfer RNA—are involved in a myriad of cell functions, including ...
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