What happens when you squeeze DNA? Can pressure reveal something about how our genetic material is packed, protected, and ...

In the early 1980s, David Gilmour, now an emeritus biochemistry and molecular biology professor at Pennsylvania State University, joined the laboratory of geneticist and biochemist John Lis as a ...

The nuclei of most human cells contains the entire genome, which would have a length of about six feet if it was fully extended. So this DNA has to be carefully compacted in cells, while still ...

Biological rhythms aren't just for sleep. In the tiny worm C. elegans, researchers in the Grosshans lab and the Computational ...

This interesting study adapts machine learning tools to analyze movements of a chromatin locus in living cells in response to serum starvation. The machine learning approach developed is useful, the ...

A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils. The solution is chromatin: a complex of DNA wrapped around proteins called histones.

Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D ...