Researchers have described a large set of previously unrecognized enzymatic domains—named the Lipocone superfamily—and outlined their evolutionary pathway from bacterial defense molecules to key ...
Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...
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