The Tennessee Titans will meet the Indianapolis Colts in Week 6 after enjoying a bye in Week 5. Is it safe to start either wide receiver DeAndre Hopkins or running back Tyjae Spears in fantasy football lineups this week?

DeAndre Hopkins accumulated 13.3 fantasy points -- six catches, 73 yards and one touchdown -- in Week 3 versus the Green Bay Packers, his best game of the season. In his worst game of the season -- Week 1 versus the Chicago Bears -- Hopkins finished with 0.8 fantasy points. His stat line: one catch, eight yards, on one target.

Team Leagues ROSTERED IN: 55% of Yahoo Leagues ANALYSIS: Tennessee Titans wide receiver DeAndre Hopkins has an appealing matchup after his Week 5 bye. The veteran wide receiver faces an Indianapolis Colts defense that has surrendered 30.

Is Woods worth starting in fantasy this week? Read on as we dive into his upcoming matchup against the Patriots. Get in the game and sign up for FanDuel Fantasy today. Use our link to start playing daily fantasy.

In Week 6, wideout Jauan Jennings and the San Francisco 49ers' aerial attack will square off against the Seattle Seahawks and their seventh-ranked pass defense (183 receiving yards allowed per game).

PM ET, WR D.K. Metcalf and the Seattle Seahawks clash with the San Francisco 49ers, who have the 12th-ranked pass defense in the league (197 receiving yards allowed per game). With his upcoming matchup versus the 49ers this week,

In Week 6, quarterback Josh Allen and the Buffalo Bills' passing attack will match up with the New York Jets and their second-ranked pass defense (136.6 passing yards allowed per game). The game has a start time of 8:15 PM ET on Monday.