Get a prediction, pick and odds for the NFL Week 2 matchup between the San Francisco 49ers and the New Orleans Saints.

Left tackle Trent Williams, dealing with a knee issue, was limited in practice on Friday, ahead of the 49ers’ Week 2 clash ...

But it's Week 2, the 49ers are 1-0 and lots of their starters will be out this Sunday. I'm talking Purdy, Kittle, and possibly Ben Bartch and Jauan Jennings, too. They haven't practiced this week, ...

San Francisco 49ers quarterback Brock Purdy is a “long shot” to play against the Saints on Sunday in New Orleans, coach Kyle ...

Quarterback Brock Purdy is a long shot to play through a toe injury when the 49ers visit the New Orleans Saints on Sunday.

The 49ers enter Sunday’s game in New Orleans seeking to open a season with back-to-back road wins like in 2019, ’21 and ’23.

Following the team’s 17-13 win over its NFC West rival, the Seattle Seahawks, the 49ers placed All-Pro tight end George ...

The San Francisco 49ers aim for a second straight road win to start the season when they visit the rebuilding New Orleans ...