The cGAS-STING signaling pathway has emerged as a major focus in cancer immunotherapy because it stimulates interferon production and enhances antitumor immune responses.

Immune checkpoint inhibitors targeting PD-1 and PD-L1 have revolutionized cancer therapy, delivering long-term survival benefits in several malignancies. However, nearly half of patients show limited ...

A group of natural compounds attracting attention for their anti-aging potential has a dark side. New research shows how a ...

A receptor involved in normal physiological processes may also drive breast cancer growth when overexpressed.

More than 200 metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found ...

A newly discovered cancer trick that weakens immunotherapy may be stopped by everyday statins.

The team is led by Leanne Li of The Francis Crick Institute in London, England. Her research combines cancer biology and neuroscience to investigate how cancer communicates with peripheral nerves ...

Scientists have identified a crucial molecular switch that decides whether pancreatic cancer cells resist chemotherapy or respond to it. The key player, a gene called GATA6, keeps tumours in a more ...

In the realm of colorectal cancer (CRC), the intricate interplay between the gut microbiota and the etiological dynamics of this disease has emerged as a focal point of investigation. The gut ...

Polyamines—natural molecules found in every living cell—have become stars in the longevity world for their ability to boost cellular cleanup and support healthy aging. But there’s a dark twist: high ...