CRISPR screen maps 250 genes essential for human muscle fiber formation

Muscles make up nearly 40% of the human body and power every move we make, from a child's first steps to recovery after ...
News-Medical.Net

New workflow boosts nuclear delivery for safer gene therapy

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus.
UC San Diego Today

From Cytoplasm to Nucleus: a New Workflow to Improve Gene Therapy Odds

The new workflow was adapted from an enzymatic DNA tagging technology, DNA-TAG, previously developed in the Devaraj lab. In ...
IEEE

Enhancing Protein Function Prediction Through the Fusion of Multi-Type Biological Knowledge With Protein Language Model and Graph Neural Network

Abstract: Proteins play crucial roles in diverse biological functions. Accurately annotating their functions is essential for understanding cellular mechanisms and developing therapies for complex ...
IEEE

MSADeepLoc: Subcellular Localization Prediction Using MSA and Protein Language Model

Abstract: Protein subcellular localization (PSCL) prediction is a key research area in bioinformatics. However, most existing models have ignored the homology and diversity among protein sequences, ...