G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

An international research team led by a University of Ottawa Faculty of Medicine investigator has revealed ultra-detailed ...

Expert Rev Mol Diagn. 2009;9(2):139-156. Diagnosis AIH-score > 15 AMA-M2 Elevated aP/γ-GT Compatible histology Cholangiography Elevated aP/γ-GT pANCA IBD γ-GT = γ-glutamyl transferase; AIH = ...

A collaborative study on a plant intracellular immune receptor not only shows how an important resistance protein is activated during pathogen infection but also reveals some common operational ...

FMC-242 is a potentially best-in-class covalent allosteric inhibitor that breaks the interaction between PI3Kα and RAS, ...

From studies conducted on animals, evidence has emerged that both neutralizing activity and Fc-mediated effector functions of neutralizing antibodies provide some levels of protection against the ...

Researchers at the Medical University of Vienna have uncovered how a little-studied protein, TRAT1 (T Cell Receptor ...

Redefining Allergy Treatment with New Class of Trifunctional ECRIs designed to deliver powerful efficacy, rapid relief and complete control of ...