Clustering is commonly used in single-cell RNA-sequencing (scRNA-seq) pipelines to characterize cellular heterogeneity. However, current methods face two main limitations. First, they require ...

Textbook dogma states that nucleus-encoded genes are monocistronic, producing transcripts with a single translated open reading frame (ORF). However, highly conserved bicistronic loci are pervasive in ...

If you never eat grapefruit because you find them far too bitter, CRISPR varieties may be more to your taste. It has been shown that disabling one gene via gene editing can greatly reduce the level of ...

Activity levels of four genes linked to the Notch signaling pathway — which helps regulate cell growth, tissue repair, and immune responses in the body — may serve as blood-based biomarkers that could ...

Abstract: In this study we focus on classification tasks and apply matrix factorization techniques like principal component analysis (PCA), independent component analysis (ICA) and non-negative matrix ...

Monitoring gene activity in the brain just got a major upgrade. Rice University bioengineers have developed a novel serum marker system that can be “erased” in the bloodstream, enabling researchers to ...

A three-year-old Oliver (Ollie) Chu has become the world’s first patient to receive a revolutionary stem cell gene therapy for Hunter syndrome. This rare, progressive, inherited disorder damages the ...