Researchers reviewed how somatic mutations accumulate in normal and diseased tissues, showing that natural selection can expand clones that influence disease risk, tissue adaptation, or cellular ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

SAN FRANCISCO -- The first-line combination of olaparib (Lynparza) plus abiraterone (Zytiga) led to a significant overall survival (OS) advantage for patients with metastatic castration-resistant ...

In mCRPC patients with BRCA1/2 or ATM alterations, first-line treatment with abiraterone plus prednisone and olaparib improves OS.

Phase 1b data that continue to demonstrate potential best-in-class efficacy and safety in mCRPC; selected provisional RP2Ds and initiated dose optimization in combination with AR inhibitors ...

Researchers have created the first complete map showing how hundreds of mutations in a key cancer gene affect tumor growth. By testing every possible mutation in a critical hotspot, they found that ...

A shocking diagnosis led a writer to focus on the dispassionate medical details, until his body jolted him into confronting what he hadn’t. By Ethan Hauser Ethan Hauser is an editor on the Culture ...

Most types of cancer have become less deadly over time in adults younger than age 50 in the U.S. but colon and rectum cancers continue to cost lives at alarming rates, according to a new report from ...

In a new study, terrestrial bacteria-infecting viruses were still able to infect their E. coli hosts in near-weightless "microgravity" conditions aboard the International Space Station, but the ...

Consuming preservatives commonly found in industrially processed foods and beverages like deli meat and breakfast cereal is associated with an increased risk of cancer, according to a new study. The ...

Median ctDNA VAF max was strongly associated with OS, PFS, DFS, and ORR. Importantly, patients with detectable residual alterations at completion of prescribed chemotherapy exhibited a markedly ...

Please provide your email address to receive an email when new articles are posted on . SAN ANTONIO — Menopausal hormone therapy did not elevate risk for breast cancer among women with inherited BRCA ...