They discovered that an ongoing viral infection causes a brief but striking shift in the availability of nutrients in the ...

Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive ...

Reducing calorie intake in mouse tumour models improves anticancer immunity by enhancing metabolic and cytotoxic functions of specific immune cells, reports a new study published in the journal Nature ...

Researchers discovered a way to keep T cells from wearing out during the fight against cancer, and the approach could make immune-based treatments far more powerful. They found that tumors use a ...

cDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China dDepartment of General Surgery, The ...

Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells. The study demonstrated that inducing cancer cells to ...

Antigen presenting cells capture tumour antigen within the tumour microenvironment and migrate to tumour-draining lymph nodes where they prime tumour-reactive T cells. Tumour-reactive T cells then ...

Hypertension is a major cause of chronic kidney disease. It triggers an innate immune response that leads to further damage to the kidney's vasculature, resulting in dysfunction. We, along with others ...

Many science fiction and fantasy stories are enveloped in a warm glow, and it’s not just because of nostalgia. Some characters literally glow — from ET’s fingertip to the demon markings in this year’s ...

As a proof-of-concept, the research team recreated liver injury triggered by the antibiotic flucloxacillin, which occurs only in carriers of the HLA-B*57:01 risk gene. The model reproduced hallmark ...

A Johns Hopkins All Children’s Hospital team found that “hot-wiring” the immune microenvironment in mouse tumors, by co-activating STING and LTβR, rapidly recruits T and B cells, builds in-tumor ...