The study in brief: Cancer research//Basic research//Peer review publication//Researcher-initiated study//Computer simulation//Animal study//In vitro/In vivo//In ...

Pediatric abdominal solid tumors mainly include neuroblastoma, nephroblastoma, hepatoblastoma, and rhabdomyosarcoma. Although significant progress has been made in the treatment of these tumors with ...

Naxitamab plus GM-CSF demonstrated strong antitumor activity and manageable toxicity in patients with high-risk neuroblastoma, achieving a 75% complete response rate at the recommended phase 2 dose.

For young children living with rare diseases, they often don’t know what’s happening to them. Not fully understanding their symptoms can make kids confused or scared, serving as one of the top ...

The FDA's orphan drug designation for AMXT 1501 and DFMO offers incentives like tax credits and market exclusivity for neuroblastoma treatment. Neuroblastoma is a rare childhood cancer, responsible ...

Gene expression governs whether neuroblastoma tumor cells exist in either the adrenergic (differentiated and sensitive to treatment) or mesenchymal (less differentiated and therapy-resistant) cell ...

ABSTRACT: Introduction: Abdominal masses in children present a diagnostic challenge due to the diversity of their causes and the subtlety of clinical signs. Computed tomography (CT) plays a key role ...

When Emily's son, James, was diagnosed with neuroblastoma, pediatric cancer advocates encouraged her to travel from Washington, D.C., so James could be treated at MSK. The therapy worked, and now ...

Researchers at Karolinska Institutet and Lund University in Sweden have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer. By combining two antioxidant ...

Association of immunotherapy of high-risk neuroblastoma patients with long term infusion of dinutuximab beta with survival over short term infusion: Results from the HR-NBL1/SIOPEN trial. This is an ...

Neuroblastoma is a pediatric solid tumor characterized by dysregulation of the CDK-RB-E2F axis, leading to elevated E2F activity, uncontrolled progression through the G1/S transition and an aggressive ...