Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

A new research paper was published in Volume 18 of Aging-US on March 3, 2026, titled “P38 MAPK is involved in epigenetic regulation of fibrotic genes in replication induced senescence in lung ...

Melanie Stein, ND Clinical improvement in treatment-refractory MCAS with normal conventional biomarkers and profound oral ...

A new scientific statement on inflammation from the American College of Cardiology confirms the value of high-sensitivity C-reactive protein (hsCRP) in clinical decision-making by stressing the ...

The development of selective diacylglycerol kinase alpha (DGKα) inhibitors offers a promising strategy to restore T cell activation and enhance antitumor immunity. Combined with immune checkpoint ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

Protein kinase A (PKA) regulates many proteins, one of which is cystic fibrosis transmembrane conductance regulator (CFTR), the ion channel underlying the lethal disease cystic fibrosis. How does one ...

Regulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P 3 defines a major eukaryotic pathway for translation of extracellular cues ...

ABSTRACT: Bidens pilosa is a member of the Asteraceae family that is widely distributed across the tropics. It has been utilized by different communities both as food and medicinal herb. This plant ...

Small conductance calcium‐activated potassium (SK) channels are largely responsible for endothelium‐dependent coronary arteriolar relaxation. Endothelial SK channels are downregulated by the reduced ...