PCSK9 - Wikipedia
PCSK9 has medical importance because it acts in lipoprotein homeostasis. Agents that block PCSK9 can lower LDL particle concentrations.
PCSK9 Inhibitors: How They Manage Cholesterol and Side Effects
What are PCSK9 inhibitors? PCSK9 inhibitors are a type of cholesterol-lowering drug. They reduce your low-density lipoprotein (LDL) cholesterol or “bad” cholesterol. This medication …
PCSK9 Inhibitors: A Full List, Side Effects, and More - Healthline
Sep 9, 2025 · PCSK9 inhibitors are an injectable treatment for high LDL cholesterol that may provide a safe alternative for people who can’t take statins or who have genetic conditions that …
What are PCSK9 Inhibitors and how do they work? - Drugs.com
Aug 26, 2025 · They work by blocking PCSK9, leaving more receptors available to capture your "bad" cholesterol (LDL) for break down and removal from the blood. They are given by …
PCSK9 inhibitors: Pharmacology, adverse effects, and use
Oct 2, 2025 · Elevated levels of circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with increased low-density lipoprotein (LDL) and worse cardiovascular outcomes.
Adding a PCSK9-i to statin therapy has been shown to reduce LDL-C, arterial plaque, and cardiovascular events in research studies. Typically, PCSK9-i lower LDL-C by an additional 45 …
PCSK9 function and physiology - PMC
So, what is PCSK9 and why does it lower hepatic LDL receptor levels? PCSK9 is a 72-kd protease, expressed highly in liver, with three recognizable domains, an N-terminal prodomain, …
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): …
Jan 8, 2024 · Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia …
How Do PCSK9 Inhibitors Lower Cholesterol? - WebMD
Nov 15, 2024 · PCSK9 inhibitors are a new class of drugs that lower LDL, or “bad,” cholesterol. Right now, there are two FDA-approved medications: alirocumab (Praluent) and evolocumab …
PCSK9 gene: MedlinePlus Genetics
The PCSK9 gene provides instructions for making a protein that helps regulate the amount of cholesterol in the bloodstream. Learn about this gene and related health conditions.