Sodium channel protein type 5 subunit alpha, also known as NaV1.5 is an integral membrane protein and tetrodotoxin -resistant voltage-gated sodium channel subunit.

The SCN5A gene belongs to a family of genes that provide instructions for making sodium channels. These channels open and close at specific times to control the flow of positively …

Mutations in the SCN5A gene can cause Brugada syndrome, a genetically inherited form of idiopathic ventricular fibrillation. These data show that a trafficking defect (SCN5A mutation) …

Oct 9, 2018 · This review summarizes the current knowledge of SCN5A genetic variations in different SCN5A -related cardiac disorders and the newly developed therapy strategies …

A common SCN5A polymorphism attenuates a severe cardiac phenotype caused by a nonsense SCN5A mutation in a Chinese family with an inherited cardiac conduction defect.

Nov 14, 2025 · SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5) is a Protein Coding gene. Diseases associated with SCN5A include Sudden Infant Death Syndrome and Long Qt …

Oct 28, 2024 · In some cases, SCN5A variants appear to be the fundamental cause of cardiomyopathy, however at times the SCN5A protein may be affected as part of the overall …

Both acquired conditions associated with sodium channel dysfunction (myocardial ischaemia, heart failure) as well as inherited disorders secondary to mutations in the gene SCN5A …

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May 1, 2023 · The sodium channel family comprises a total of nine genes (SCN1A-SCN5A, SCN7A-SCN11A), of which the SCN5A gene located on human chromosome 3p22 encodes …