New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Feb 18, 2025 · Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s disease. In the …
Phospho-Tau Might Take Down Viruses | ALZFORUM
Jan 9, 2026 · Phosphorylated tau isn’t just pathological junk; it helps the brain defend against viral infections. So claim scientists led by Rudolph Tanzi and William Eimer at Massachusetts General …
Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
Jan 30, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. The …
Despite Phase 2 Strike-Out, New Tau Antibodies Step Up to Plate
More antibodies take aim at seeded propagation. New data ties tangle location to deficits in specific cognitive domains. Three first-in-human studies for antibodies targeting different parts of tau suggest …
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
Feb 1, 2025 · To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time. It showed that ApoE3Ch clings onto tau monomers …
LY3954068 | ALZFORUM
Nov 25, 2024 · LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau. No information is available about the makeup of LY3954068.
Better Diagnosis with Blood Test Detecting Only Tau Made in Brain
Dec 29, 2022 · In the December 27 Brain, Karikari reported that plasma concentration of these brain-derived forms of tau (BD-tau) tracked with cerebrospinal fluid markers of amyloid plaques and of …
Tau (PHF-1) | ALZFORUM
Feb 5, 2024 · PHF-1 reacts with tau phosphorylated at serine-396 and serine-404. Western blot of recombinant human tau phosphorylated in vitro with GSK3β, probed with PHF-1. WT, wild-type tau; …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · Tau plays an essential role in the production of these droplets, according to a paper in the October Nature Neuroscience. Using a combination of fly and mammalian cell models, scientists …