T helper 17 cells (Th17) are a subset of pro-inflammatory T helper cells defined by their production of interleukin 17 (IL-17). They are related to T regulatory cells and the signals that …

Learn more about T helper 17 cells (Th17 cells), including T helper 17 cell activation, differentiation, and function.

In this review, we discuss the heterogeneity of Th17 cells and the role of this heterogeneity in diverse functions of Th17 cells from homeostasis to tissue inflammation.

Subsequent research using animal models and human studies has demonstrated a key role for Th17 cells in the immune system’s defence against extracellular bacteria and fungi as well as …

Sep 1, 2025 · Autoimmune diseases occur when the immune system mistakenly attacks the body. T helper 17 (Th17) cells, a type of immune cell, play a significant role in these diseases.

Aug 25, 2025 · Here, we aimed to elucidate the CD5-CK2-STAT3 axis in human Th17 function. We demonstrate that blockade of CD5 impairs production of pro-inflammatory cytokines by …

Th17 cells are a subset of CD4+ T helper cells that develop in the presence of IL-6 and TGF-β, characterized by the production of IL-17, TNF-α, and IL-22, and the expression of the …

Jul 31, 2025 · Th17 cells primarily function in host defense against extracellular bacteria and fungi. They are abundant at mucosal surfaces like the gut, lungs, and skin, forming a first line …

Jun 29, 2023 · At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play …

Oct 27, 2024 · In this review, we aim to elucidate the complexities of Th17 cell function in cancer by summarizing recent studies and, ultimately, to design novel therapeutic strategies, …