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Cells detect so much more than whether a signal is ON or OFF.This elegant @eLife study showed that use of a pulsed optogenetic controller of the Wnt pathway demonstrates how the temporal pattern of the light stimulation determines the cell state - either activating or suppressing Wnt, a key regulator of cell fate, proliferation, and development.While optogenetics is a synthetic tool, it reveals a deeper principle. Cells interpret the timing of signals, with temporal variation acting as an instru
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