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1. Hodgkin lymphoma. Severe, generalized itching—often worse at night, may precede lymphadenopathy 2. Polycythemia Vera. Aquagenic pruritus (itching after warm showers, no rash) Seen years before diagnosis 3. Gall bladder & pancreatic cancer. Bile salt deposition in skin. Intense itching, possible jaundice, dark urine, pale stools 4. Cutaneous T-cell lymphoma. Severe itching, eczema-like rash
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